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Epithalon 10mg

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Products/Epithalon 10mg

Epithalon 10mg

Epithalon 10mg

Important NoticeThis product is for use only in vitro research. It is strictly prohibited for human injection, clinical treatment, food addition or any animal experiments. Please read our terms and conditions carefully before placing an order.
Purity / identity≥99% purity
Molecular weight390.35 g/mol
Pack size10mg

Volume pricing

Configured totals update at each quantity threshold.

Configured total$24.05
Open COA / MSDS
SKU: ps-epithalon-20mg

Research record

Pending manual confirmation

Research overview

Epithalon (also known as Epitalon or AEDG) is a synthetic tetrapeptide composed of four amino acids (Ala-Glu-Asp-Gly). Its core mechanism of action centers on telomerase regulation and neuroendocrine system restoration: it upregulates telomerase activity through epigenetic activation of the hTERT promoter, restoring enzymatic activity and elongating telomeres in telomerase-negative human fibroblasts, making it one of the very few molecules demonstrated to reactivate the telomerase gene in somatic cells. As a pineal peptide analog, it restores age-related circadian rhythm disruptions in melatonin and cortisol secretion. Its geroprotective effects are further supported by multiple mechanisms, including antioxidant, neuroprotective, and anti-mutagenic activities.

Research reference

Product FAQ

What is Epithalon?

Epithalon (also known as Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. This compound is renowned for its ability to extend telomeres by activating telomerase, and thus has gained significant attention in the fields of anti-aging and longevity research.

What is the mechanism of action of Epithalon?

Epithalon works through several primary mechanisms:

· Telomerase activation: Activates telomerase reverse transcriptase (TERT), lengthening telomeres and delaying cellular senescence

· Melatonin modulation: Stimulates the pineal gland to produce melatonin, restoring age-related declines in melatonin rhythmicity

· Gene expression regulation: Modulates the expression of approximately 100 genes associated with aging

· Oxidative stress resistance: Reduces ROS production and enhances cellular antioxidant defenses

· Immunomodulation: Modulates immune responses by improving thymus and immune cell function

Does Epithalon have research value for the immune system?

Yes. Studies show Epithalon modulates immune function through multiple pathways:

· Promoting T cell proliferation and differentiation

· Enhancing natural killer (NK) cell activity

· Increasing thymus mass (reversing age-related thymic involution)

· Improving antibody responses

· Modulating cytokine production

This makes it potentially valuable in research on immunosenescence and infection prevention.

What are the main research areas for Epithalon?

· Anti-aging and lifespan extension

· Telomere length regulation

· Age-related diseases (cardiovascular, neurodegenerative)

· Sleep cycle regulation (melatonin modulation)

· Immune system function modulation

· Retinal and eye disorders

· Cancer research (as a preventive and adjunctive agent)

Data sheet

Manual confirmation
Material Type
Single material
Purity Identity
≥99% purity
Molecular Weight
390.35 g/mol
Pack Size
10mg
Molecular Formula
C14H22N4O9
CAS Number
307297-39-8
Amino Acid Sequence
Ala-Glu-Asp-Gly
PubChem CID
219042
Storage conditions overview
Storage typeLong-termTemperature-80°CDuration2-3 yearsNotesSealed, dark, minimal opening
Storage typeStandardTemperature-20°CDuration1-2 yearsNotesSealed, dark, moisture-proof
Storage typeShort-termTemperature4°CDuration1-2 weeksNotesTemporary storage, use promptly
Storage typeWorking SolutionTemperature4°CDuration1-7 daysNotesReconstituted, short-term, avoid freeze-thaw

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