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Hexarelin 5mg
Research-use peptide material record: pack format, specifications and COA/SDS request for qualified laboratory review.
RESEARCH USE ONLYRUO
Hexarelin 5mg
Important NoticeThis product is for use only in vitro research. It is strictly prohibited for human injection, clinical treatment, food addition or any animal experiments. Please read our terms and conditions carefully before placing an order.
Volume pricing
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Configured total$26.42
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Research record
Pending manual confirmationResearch overview
Hexarelin is a synthetic hexapeptide (6 amino acids) belonging to the growth hormone‑releasing peptide (GHRP) family and is a stabilized modified analogue of GHRP‑6. As a highly effective agonist of the growth hormone secretagogue receptor (GHS‑R), Hexarelin acts at both the pituitary and hypothalamic levels to stimulate pulsatile endogenous growth hormone (GH) release via activation of GHS‑R1a. The presence of a 2‑methyltryptophan (2‑Me‑Trp) substitution in its structure confers greater stability and more sustained GH‑releasing activity compared to the parent compound GHRP‑6. Beyond its classical GH‑releasing function, Hexarelin also exhibits non‑GHSR‑dependent cardioprotective effects: it binds to the CD36 receptor, improves cardiac contractility, reduces myocardial ischemia–reperfusion injury, and inhibits myocardial fibrosis. In addition, studies have suggested potential activities in pancreatic β‑cell protection and anti‑apoptosis. Hexarelin has progressed to Phase II clinical trials for growth hormone deficiency and congestive heart failure.
Research reference
Product FAQ
What is Hexarelin?
Hexarelin is a synthetic hexapeptide belonging to the growth hormone-releasing peptide (GHRP) family and is a stabilized modified analogue of GHRP-6. As a potent agonist of the GHS-R1a receptor, it acts simultaneously at the pituitary and hypothalamic levels to stimulate the pulsatile release of endogenous growth hormone (GH). The 2-methyltryptophan (2-Me-Trp) substitution in its structure gives it stronger stability and more persistent GH-releasing activity compared to GHRP-6.
What is the mechanism of action of Hexarelin?
Hexarelin works through a dual mechanism:
GHSR-1a receptor agonism: Activates GHS-R1a receptors in the pituitary and hypothalamus, stimulating pulsatile GH release and subsequently elevating IGF-1 levels.
CD36 receptor binding (GHSR-independent): Directly binds to the CD36 receptor, improving cardiac contractility, reducing myocardial ischemia-reperfusion injury, and inhibiting myocardial fibrosis.
Does Hexarelin have research value for the cardiovascular system?
Yes. Besides its GH-releasing function, Hexarelin exerts GHSR-independent cardioprotective effects by binding to the CD36 receptor. Studies show that Hexarelin improves cardiac contractility, reduces myocardial ischemia-reperfusion injury, and inhibits myocardial fibrosis, making it uniquely valuable in cardiovascular disease research.
Does Hexarelin have research value for pancreatic β-cells?
Yes. Studies have found that Hexarelin exhibits pancreatic β-cell protective and anti-apoptotic activities, suggesting potential value in diabetes research. This effect appears to be independent of its GH-releasing activity, and the exact mechanisms are still being explored.
What are the main research areas for Hexarelin?
· Growth hormone deficiency
·Short stature in children
· Cardioprotection (myocardial ischemia/reperfusion injury, myocardial fibrosis)
· Anti-aging research
· Metabolic regulation
· Pancreatic β-cell protection
Data sheet
Manual confirmation- Material Type
- Single material
- Purity Identity
- ≥99% purity
- Molecular Weight
- 887.04 g/mol
- Pack Size
- 5mg
- Molecular Formula
- C47H58N12O6
- CAS Number
- 140703-51-1
- Amino Acid Sequence
- H-His-D-Trp(2-Me)-Ala-Trp-D-Phe-Lys-NH2
- PubChem CID
- 6918297
- Storage conditions overview
- Storage typeLong-termTemperature-80°CDuration2-3 yearsNotesSealed, dark, minimal openingStorage typeStandardTemperature-20°CDuration1-2 yearsNotesSealed, dark, moisture-proofStorage typeShort-termTemperature4°CDuration1-2 weeksNotesTemporary storage, use promptlyStorage typeWorking SolutionTemperature4°CDuration1-7 daysNotesReconstituted, short-term, avoid freeze-thaw
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