Research Models & Evidence
PEPTIDES BIO / MATERIAL RECORD
AOD-9604 5mg
Research-use peptide material record: pack format, specifications and COA/SDS request for qualified laboratory review.
RESEARCH USE ONLYRUO
AOD-9604 5mg
Important NoticeThis product is for use only in vitro research. It is strictly prohibited for human injection, clinical treatment, food addition or any animal experiments. Please read our terms and conditions carefully before placing an order.
Volume pricing
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Configured total$28.19
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Research record
Pending manual confirmationResearch overview
AOD‑9604 is a synthetic 15‑amino‑acid polypeptide derived from the C‑terminal segment (residues 177–191) of human growth hormone (hGH). Its primary function is to mimic the lipolytic (fat‑breaking) activity of growth hormone while avoiding side effects associated with full‑length hGH, such as proliferative effects and hyperglycemia. AOD‑9604 stimulates lipolysis—i.e., the breakdown of fat—and inhibits lipogenesis, thereby preventing the conversion of non‑lipid substrates into body fat. Unlike full‑length growth hormone, AOD‑9604 does not target the classical growth hormone receptor. Its lipolytic effect is thought to be mediated primarily via the β3‑adrenergic receptor (β3‑AR) pathway. Chronic administration upregulates β3‑AR RNA expression in adipocytes, and in β3‑AR knockout mice, its weight‑reducing effect is abolished. Moreover, because it does not act through the IGF‑1 pathway, it has no adverse impact on carbohydrate metabolism.
Research reference
Product FAQ
What is AOD-9604?
AOD-9604 is a synthetic peptide fragment derived from the C-terminus of human growth hormone (hGH), originally investigated for its lipolytic (fat-burning) effects. Unlike full-length hGH, it does not act through the hGH receptor and does not affect blood glucose or systemic IGF-1 levels.
What is the mechanism of action of AOD-9604?
AOD-9604 promotes fat metabolism through AMPK pathway activation and may support cartilage repair. Unlike full-length hGH, it does not stimulate IGF-1 secretion and does not cause hyperglycemia or insulin resistance. In animal studies, it reduces weight gain by increasing fat oxidation and lipolysis.
Does AOD-9604 have research value in osteoarthritis?
Yes. In a rabbit model of osteoarthritis, intra-articular injection of AOD-9604 combined with hyaluronic acid (HA) demonstrated improvements in cartilage morphology and joint surface integrity. AOD-9604 has been explored in some regenerative protocols for osteoarthritis.
Is AOD-9604 used in sports medicine?
AOD-9604, along with other growth hormone secretagogues, is being explored in sports medicine for muscle repair and recovery through GH/IGF-1 axis activation. However, it is prohibited for professional athletes by WADA.
What are the main research areas for AOD-9604?
· Obesity and weight management
· Lipid metabolism and energy expenditure
· Osteoarthritis and cartilage repair
· Musculoskeletal injury recovery
Data sheet
Manual confirmation- Material Type
- Single material
- Purity Identity
- ≥99% purity
- Molecular Weight
- 1815.1 g/mol
- Pack Size
- 5mg
- Molecular Formula
- C78H123N23O23S2
- CAS Number
- 221231-10-3
- Amino Acid Sequence
- YLRIVQCRSVEGSCGF
- PubChem CID
- 71300630
- Storage conditions overview
- Storage typeLong-termTemperature-80°CDuration2-3 yearsNotesSealed, dark, minimal openingStorage typeStandardTemperature-20°CDuration1-2 yearsNotesSealed, dark, moisture-proofStorage typeShort-termTemperature4°CDuration1-2 weeksNotesTemporary storage, use promptlyStorage typeWorking SolutionTemperature4°CDuration1-7 daysNotesReconstituted, short-term, avoid freeze-thaw