AOD-9604 in Mouse Models and the WADA hGH Isoform Immunoassay

Research use only. The cited records describe named experimental systems and do not provide human or veterinary use, dosing, administration, safety, or outcome guidance.

Two AOD-9604 records answer different questions

PMID 11713213 is an in vivo mouse paper. PMID 24124033 is a report titled AOD-9604 does not influence the WADA hGH isoform immunoassay. Their common material term does not make their methods, measurements, or limits interchangeable.

Mouse-model record: obese mice and beta3-AR knockout mice

Heffernan et al. (2001; PMID 11713213) compares human growth hormone and the C-terminal fragment named AOD9604 in obese mice and beta3-adrenergic-receptor knockout mice. The article reports a 14-day mouse experiment, beta3-AR RNA expression, and the authors’ named physiological and lipolysis-related measurements. It also describes a separate acute experiment in the knockout-mouse system.

Those observations belong to the authors’ mouse strains, comparators, timing, and measurements. The paper does not report a receptor-binding experiment, an analytical purity result, or a result for another species, model, or received material lot.

Assay record: WADA hGH isoform immunoassay

Orlovius et al. (2013; PMID 24124033) addresses whether AOD-9604 influences the WADA human-growth-hormone isoform immunoassay. The public record identifies that assay question in the title; it is not a mouse-model paper. The PubMed record is a Letter whose title states the assay question. It does not attribute the mouse-model measurements reported in PMID 11713213 to this immunoassay record.

Keep the source fields with the matching citation

• For PMID 11713213: retain the obese-mouse or beta3-AR knockout context, the hGH and AOD9604 comparators, the reported time frame, and the stated measurements.
• For PMID 24124033: retain the WADA hGH isoform immunoassay as the study question and do not transfer mouse-model measurements to that record.
• For material documentation: retain the received label, lot identifier, receipt date, and supplied documents independently from both publications.

Evidence boundary

Neither cited source establishes the identity, composition, purity, manufacture, or performance of a different catalogue batch. The mouse paper and the immunoassay record can be cited for the specific systems they report; they do not support a claim about a different model or a use recommendation.