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PEPTIDES BIO / MATERIAL RECORD
CJC-1295 no DAC 5mg
Research-use peptide material record: pack format, specifications and COA/SDS request for qualified laboratory review.
RESEARCH USE ONLYRUO
CJC-1295 no DAC 5mg
Important NoticeThis product is for use only in vitro research. It is strictly prohibited for human injection, clinical treatment, food addition or any animal experiments. Please read our terms and conditions carefully before placing an order.
Volume pricing
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Configured total$21.14
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Research record
Pending manual confirmationResearch overview
CJC‑1295 without DAC (also known as modified GRF(1–29) or Mod GRF(1–29)) is a synthetic growth hormone‑releasing hormone (GHRH) analogue comprising 29 amino acids. It incorporates four amino acid substitutions at sites prone to enzymatic cleavage in native GHRH, is prepared by solid‑phase peptide synthesis, and acts on the GHRH receptor (GHRH‑R). As a stable GHRH analogue, CJC‑1295 without DAC has a significantly shorter half‑life than its DAC‑containing counterpart. This pharmacokinetic profile makes it widely used in preclinical neuroendocrine studies to mimic the intermittent pulsatile secretion pattern of endogenous GHRH. In vitro experiments using rat anterior pituitary cells have investigated its binding affinity to GHRH‑R and receptor activation kinetics, with adenylate cyclase activation and intracellular cAMP accumulation serving as primary functional readouts. Further studies in rodent models have examined its effects on the growth factor axis—both alone and in combination—with particular emphasis on GH release kinetics when co‑administered with GHRP‑6 and other secretagogues, thereby providing experimental evidence for understanding the pulsatile regulation of GH.
Research reference
Product FAQ
What is CJC-1295 no DAC?
CJC-1295 no DAC is a synthetic peptide belonging to the growth hormone secretagogue (GHS) class. It is the original form of CJC-1295 without the Drug Affinity Complex (DAC) modification. By agonizing the GHRH receptor, it stimulates the pituitary gland to release growth hormone (GH) in a pulsatile manner, which in turn elevates IGF-1 levels. The no-DAC version has a shorter half-life, mimicking a more physiological GH pulse pattern.
What is the mechanism of action of CJC-1295 no DAC?
CJC-1295 no DAC works by binding to and activating the GHRH receptor on the anterior pituitary gland, triggering the synthesis and pulsatile release of GH. The resulting GH pulses stimulate the liver to produce IGF-1, which mediates most of the anabolic effects, including protein synthesis, lipolysis, and cell proliferation. The short half-life (~30-60 minutes) of the no-DAC version allows for rapid clearance and maintains a natural GH pulse pattern.
Is there clinical research supporting CJC-1295 no DAC?
Yes. CJC-1295 (without DAC) has completed multiple Phase 1 and 2 clinical trials in healthy subjects and GH-deficient patients. Studies have confirmed that it safely and effectively elevates GH and IGF-1 levels.
Does CJC-1295 no DAC have research value for sleep quality?
Yes. GH secretion is highly correlated with slow-wave sleep (deep sleep), with most GH released during early sleep. CJC-1295 no DAC, with its pulsatile GH release pattern, more closely mimics the natural circadian rhythm and is therefore considered superior to the DAC version in sleep research. Studies suggest it may indirectly improve sleep quality by enhancing nighttime GH peaks.
What are the main research areas for CJC-1295 no DAC?
· Growth hormone deficiency
· Muscle wasting and atrophy
· Fat metabolism and weight loss
· Anti-aging research
· Sleep quality improvement
· Bone density enhancement
· Tissue repair and regeneration
Data sheet
Manual confirmation- Material Type
- Single material
- Purity Identity
- ≥99% purity
- Molecular Weight
- 3367.89 g/mol
- Pack Size
- 5mg
- Molecular Formula
- C152H252N44O42
- CAS Number
- 863288-34-0
- Amino Acid Sequence
- H-Y{d}ADAIFTQSYRKVLAQLSARKLLQDILSR-[NH2]
- PubChem CID
- 56841945
- Storage conditions overview
- Storage typeLong-termTemperature-80°CDuration2-3 yearsNotesSealed, dark, minimal openingStorage typeStandardTemperature-20°CDuration1-2 yearsNotesSealed, dark, moisture-proofStorage typeShort-termTemperature4°CDuration1-2 weeksNotesTemporary storage, use promptlyStorage typeWorking SolutionTemperature4°CDuration1-7 daysNotesReconstituted, short-term, avoid freeze-thaw