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CJC-1295 with DAC 5mg
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RESEARCH USE ONLYRUO
CJC-1295 with DAC 5mg
Important NoticeThis product is for use only in vitro research. It is strictly prohibited for human injection, clinical treatment, food addition or any animal experiments. Please read our terms and conditions carefully before placing an order.
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Research record
Pending manual confirmationResearch overview
CJC‑1295 is a synthetic growth hormone‑releasing hormone (GHRH) analogue containing a drug‑affinity complex (DAC). It consists of 30 amino acids and features a malonyl‑acyl group linked to the C‑terminal lysine residue to enhance high‑affinity binding to serum albumin. This peptide is prepared by solid‑phase peptide synthesis and acts on the GHRH receptor (GHRH‑R). In preclinical endocrinology studies, CJC‑1295 DAC has attracted attention due to its superior pharmacokinetic profile relative to unmodified GHRH analogues. The core innovation lies in its DAC‑mediated bioconjugation strategy, which prolongs peptide half‑life through albumin binding rather than simple sequence modification—a mechanism that has become a key research focus. In vitro experiments using a rat anterior pituitary cell model have systematically characterized the binding of CJC‑1295 DAC to GHRH‑R and its downstream cAMP signaling pathway, including receptor‑binding kinetic parameters, thereby confirming its activity as a GHRH‑R agonist. Pharmacokinetic studies in rodent models demonstrated that a single administration resulted in sustained circulating peptide levels and significantly prolonged receptor occupancy. Further investigation of albumin–peptide dissociation kinetics and their impact on receptor occupancy duration has provided important insights into the long‑lasting effects of this compound.
Research reference
Product FAQ
What is CJC-1295 with DAC?
CJC-1295 with DAC is a synthetic peptide belonging to the growth hormone secretagogue (GHS) class. It is a modified version of CJC-1295, where DAC (Drug Affinity Complex) is an albumin-binding domain that significantly extends the peptide's half-life in the body. Through agonism of the GHRH receptor, it stimulates the pituitary gland to secrete more growth hormone (GH) and insulin-like growth factor-1 (IGF-1).
What is the mechanism of action of CJC-1295 with DAC?
CJC-1295 with DAC works by binding to and activating the GHRH receptor on the anterior pituitary gland, triggering the synthesis and pulsatile release of growth hormone. The resulting GH elevation stimulates the liver to produce IGF-1, which mediates most of the anabolic effects, including protein synthesis, lipolysis, and cell proliferation. The DAC moiety binds to serum albumin, extending the peptide's half-life and allowing for weekly administration rather than daily.
What is the value of combining CJC-1295 with DAC and Ipamorelin?
CJC-1295 with DAC and Ipamorelin work through different mechanisms: CJC-1295 stimulates the GHRH receptor, while Ipamorelin is a GHRP that amplifies GH pulses by activating the GHSR. The combination can produce a synergistic effect—CJC-1295 provides sustained baseline stimulation, while Ipamorelin provides pulse amplification. This combination has been extensively explored in research to achieve a more physiological GH release pattern.
Does CJC-1295 with DAC have research value for sleep quality?
Yes. GH secretion is highly correlated with slow-wave sleep (deep sleep), with the majority of GH released during early sleep. CJC-1295 with DAC may indirectly improve sleep quality by elevating GH levels, particularly in older adults whose GH secretion naturally declines. However, direct studies are still ongoing, and no large-scale trials specifically targeting sleep endpoints have been conducted.
What are the main research areas for CJC-1295 with DAC?
· Growth hormone deficiency
· Muscle wasting and atrophy
· Fat metabolism and weight loss
· Anti-aging research
· Sleep quality improvement
· Bone density enhancement
· Wound healing and tissue repair
Data sheet
Manual confirmation- Material Type
- Single material
- Purity Identity
- ≥99% purity
- Molecular Weight
- 3647.19 g/mol
- Pack Size
- 5 mg
- Molecular Formula
- C165H269N47O46
- CAS Number
- 446262-90-4
- Amino Acid Sequence
- H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys-Lys(Maleimidopropionyl)-NH2
- PubChem CID
- 91971820
- Storage conditions overview
- Storage typeLong-termTemperature-80°CDuration2-3 yearsNotesSealed, dark, minimal openingStorage typeStandardTemperature-20°CDuration1-2 yearsNotesSealed, dark, moisture-proofStorage typeShort-termTemperature4°CDuration1-2 weeksNotesTemporary storage, use promptlyStorage typeWorking SolutionTemperature4°CDuration1-7 daysNotesReconstituted, short-term, avoid freeze-thaw