Melanotan I 10mg

Melanotan I (also known as MT-1) is a synthetic analogue of α-melanocyte-stimulating hormone (α-MSH), composed of 13 amino acids. It stimulates melanocytes to produce melanin by activating the melanocortin-1 receptor (MC1R), thereby inducing skin tanning. Unlike Melanotan II, Melanotan I is structurally closer to natural α-MSH and has higher selectivity for MC1R over other melanocortin receptors.

Melanotan I works by binding to and activating the MC1R receptor on the surface of skin melanocytes. Activated MC1R initiates a signaling cascade (primarily through the cAMP/PKA pathway), promoting the synthesis and activity of tyrosinase, which converts tyrosine into melanin. The resulting melanin (primarily eumelanin) accumulates in keratinocytes, providing darker skin color and natural protection against UV radiation.

Yes. Melanotan I has been most extensively studied in photosensitive skin disorders such as EPP. EPP patients suffer from the accumulation of photosensitive substances due to enzyme deficiencies, causing severe pain upon sunlight exposure. By increasing skin melanin content to provide photoprotection, Melanotan I has been shown to significantly reduce sun-induced pain and improve quality of life in EPP patients.

Yes. Vitiligo is an autoimmune disease in which melanocytes are destroyed, leading to white patches on the skin. Theoretically, by stimulating melanin production in remaining melanocytes through MC1R agonism, Melanotan I may help repigment depigmented areas. Some exploratory studies are currently evaluating its potential in vitiligo treatment, but research in this area is still in its early stages.

· Skin photoprotection (prevention of UV damage)

· Artificial tanning (achieving skin color without prolonged sun exposure)

· Photosensitive skin disorders (e.g., erythropoietic protoporphyria, EPP)

· Vitiligo

· Repair of sun-related skin damage

· MC1R signaling pathway research