PEPTIDES BIO / QUALITY & DOCUMENTATION
MOTS-C: A Research Overview for Material Review
A MOTS-C research guide covering mitochondrial-peptide context, model-based literature review, and material-record limits.
Research or raw-material evaluation only. Not for human or veterinary use.
MOTS-C is a 16-amino-acid mitochondrial-encoded research peptide, and its published findings answer two different questions: how it relates to cellular energy signalling and what happened in defined mouse models. The original study reported AMPK-linked cellular changes and protection against diet-associated metabolic changes in mice; a later study observed movement of MOTS-C into the nucleus during cellular metabolic stress. The catalogue offers a 10 mg and a 20 mg research-material format.
What the MOTS-C experiments found
| Published source | System and measurement | Reported finding |
|---|---|---|
| Lee et al., 2015 | A short open reading frame within mitochondrial 12S rRNA; cellular metabolism and mouse models. | The authors identified a 16-amino-acid peptide, described inhibition of the folate-linked purine pathway with AMPK activation, and reported prevention of age- and high-fat-diet-associated insulin resistance in the studied mice. |
| Kim et al., 2018 | Cellular metabolic stress, nuclear localisation and gene-expression measurements. | MOTS-C moved to the nucleus after metabolic stress and was associated with an AMPK-dependent gene-expression response under glucose restriction. |
These are distinct experiments, not one universal outcome. The cell study helps a reader ask about signalling and localisation; the mouse study adds an organism-level research model. Read the original MOTS-C report and the metabolic-stress study.
MOTS-C research material at a glance
For a material enquiry, start with the intended model and the required amount. The MOTS-C 10 mg product page links to a product COA file; the 20 mg page provides another catalogue format. A useful request names the pack size and asks for the analytical records relevant to the planned work. The literature describes experiments performed by the cited authors, while the product pages identify the material being offered here.
Which research question should the next experiment answer?
- For cell signalling, identify the cell system, stress condition and AMPK-related endpoint.
- For mouse-model literature, keep the diet or age context, comparator and measured metabolic outcome together.
- For material selection, use the product format and its analytical documentation to make a precise request.
Choose the 10 mg or 20 mg listing, then send the team your project requirements for availability and a quote. The cited cell and mouse observations are research context, not a claim of human outcomes for a catalogue material.
References
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