PT-141 in a Female Rat Behavioral Study: Model and Reported Measures

Research use only. The source below describes a defined rat experiment. It does not provide human or veterinary use, dosing, administration, safety, or outcome guidance.

What the cited study identifies

Pfaus et al. (2004; PMID 15226502) identifies PT-141 as a peptide analogue of alpha-melanocyte-stimulating hormone and describes its interaction with central melanocortin receptors in the context of the authors’ rat experiment. PubChem records the synonym Bremelanotide for the named compound. These identity records do not identify the sequence, purity, lot, or manufacture of a separately received catalogue material.

Experimental system in PMID 15226502

The paper studied ovariectomized Long-Evans female rats paired with sexually vigorous Long-Evans male rats. The methods describe estrogen-and-progesterone-primed and estrogen-alone groups. Before the PT-141 tests, the females underwent ten preliminary behavioural tests; the article states that testing occurred at four-day intervals during the middle third of the dark circadian cycle.

Two chamber configurations were used. In bilevel chambers, the authors recorded a 30-minute interaction after random assignment to PT-141 or saline control conditions. In unilevel pacing chambers, a Plexiglas divider allowed the female, but not the male, to cross between sides. The paper also reports an open-field locomotion assessment and a conditioned-place-preference experiment. Those systems are part of this publication’s design; they are not a receptor-subtype binding assay.

Reported measures stay with the model

The behavioural records included latency and frequency of solicitation, hops and darts, pacing, rejection responses, and lordosis quotients. The unilevel-chamber experiment additionally recorded female-to-male mounting and return latencies after mounting, intromission, or ejaculation. The open-field assessment used grid crossings, and the conditioned-place-preference assessment recorded time in the apparatus compartments.

The article reports its observations for those animals, priming conditions, chamber configurations, comparators, and measures. It does not report a human dataset, a catalogue-material analysis, an analytical purity result, or a receptor-subtype experiment that assigns a specific result to one melanocortin receptor.

Source boundary

PMID 15226502 can support a source note about this defined Long-Evans rat behavioural study and the measurements named by its authors. It cannot establish the identity or performance of another lot, transfer the observations to another species or experimental system, or substitute for a material-specific certificate or batch record.