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SS-31 / Elamipretide: Identity, Nomenclature and Documentation Review

A source-checked SS-31 guide for matching literature names, experimental records, and batch documentation.

Published Updated Published byPeptides Bio

Research or raw-material evaluation only. Not for human or veterinary use.

SS-31, also called elamipretide in the cited research, is studied for its interactions with the mitochondrial inner membrane. Two useful papers answer different questions: one connects SS-31 and a fluorescent analogue to cardiolipin and ATP recovery in an ischemia model; the other maps proteins interacting with a modified SS-31 probe in isolated mitochondria. The SS-31 10 mg catalogue page is the starting point for material availability and documentation.

SS-31 research diagram separating cardiolipin and rat ischemia observations from protein-interaction mass-spectrometry findings
One study investigated cardiolipin and a rat model; another mapped mitochondrial protein interactions.

Two experiments, two different observations

Study Material and method Reported observation
Birk et al., 2013 A polarity-sensitive fluorescent SS-31 analogue for cardiolipin interaction, plus a rat renal-ischemia model. The analogue showed high-affinity interaction with cardiolipin; rat experiments reported preservation of cristae structure and faster ATP recovery on reperfusion after SS-31 pretreatment.
Chavez et al., 2020 A chemically modified SS-31 probe, cross-linking and mass spectrometry in mitochondrial preparations. The authors identified interacting proteins associated with oxidative phosphorylation and 2-oxoglutarate processes, adding a protein-interaction map to the cardiolipin picture.

Read the cardiolipin and ischemia study and the protein-interaction study. The fluorescent and cross-linkable probes serve experimental detection; they are not presented here as specifications of the offered material.

SS-31 material overview for a research enquiry

The product is listed as SS-31 10 mg. A focused request can specify whether the work needs identity confirmation, an analytical method discussion or an assay-related material question. No public COA file is linked on the product page at this review, so this guide does not invent a purity result or claim that either paper tested the product being sold.

Put the next question next to the right evidence

  1. Membrane mechanism: start with the cardiolipin-interaction methods and the precise probe used.
  2. Protein partners: use the cross-linking and mass-spectrometry study, keeping its modified probe in view.
  3. Research procurement: use the SS-31 10 mg page and send a material and documentation enquiry.

The published experiments are research context, not clinical outcomes or product-lot test results.

References

  1. PubChem compound record: Elamipretide (CID 11764719)
  2. Birk et al., 2013: SS-31 and cardiolipin interaction (PMID 23813215)
  3. Chavez et al., 2020: SS-31 interaction landscape (PMID 32554501)

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