Peptide Identity & Structure
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SS-31 10mg
Research-use peptide material record: pack format, specifications and COA/SDS request for qualified laboratory review.
RESEARCH USE ONLYRUO
SS-31 10mg
Important NoticeThis product is for use only in vitro research. It is strictly prohibited for human injection, clinical treatment, food addition or any animal experiments. Please read our terms and conditions carefully before placing an order.
Volume pricing
Configured totals update at each quantity threshold.
Configured total$29.78
Request COA / MSDS
Research record
Pending manual confirmationResearch overview
SS‑31, officially known as Elamipretide or MTP‑131, is a synthetic tetrapeptide composed of four amino acids. Unlike conventional free‑radical scavengers, SS‑31 is a mitochondria‑targeted peptide that selectively accumulates in the inner mitochondrial membrane. Its primary molecular target is cardiolipin—a phospholipid found almost exclusively in the inner mitochondrial membrane. By specifically binding to cardiolipin, SS‑31 stabilizes mitochondrial cristae architecture, preserves the integrity of the respiratory chain, reduces mitochondrial reactive oxygen species (ROS) production, and enhances ATP synthesis. In contrast to ordinary antioxidants that directly scavenge free radicals, SS‑31 attenuates oxidative damage at its source by repairing the mitochondrial membrane structure.
Research reference
Product FAQ
What is SS-31?
A mitochondria‑targeting tetrapeptide (also known as Elamipretide, MTP‑131, Bendavia) that stabilizes mitochondrial structure by binding to cardiolipin on the inner mitochondrial membrane, reducing ROS production and enhancing ATP synthesis.
What is the mechanism of action of SS‑31?
SS‑31 selectively accumulates in the inner mitochondrial membrane, binds to cardiolipin, stabilizes cristae structure, inhibits cytochrome c peroxidase activity, and reduces oxidative damage. It also inhibits mitochondrial permeability transition pore opening, increases ATP synthesis, and exhibits anti‑inflammatory effects.
Is there clinical research supporting SS‑31?
Yes. In 2025, SS‑31 received FDA accelerated approval for Barth syndrome, a rare mitochondrial disease. It is also in clinical trials for multiple indications including heart failure, kidney injury, and ophthalmic diseases.
How does SS‑31 differ from common antioxidants?
Traditional antioxidants like Coenzyme Q10 and MitoQ do not specifically target mitochondrial membrane components. SS‑31 precisely targets the inner mitochondrial membrane by binding to cardiolipin, achieving 1000‑5000‑fold accumulation in mitochondria with high specificity.
What are the main research areas for SS‑31?
Research covers a wide range of areas, including:
· Neurodegenerative diseases (Parkinson's, Alzheimer's, etc.)
· Cardiovascular diseases (myocardial infarction, ischemia‑reperfusion injury, heart failure)
· Aging and age‑related diseases (muscle aging, osteoarthritis)
· Kidney diseases (acute kidney injury)
· Ophthalmic diseases (glaucoma)
· Female reproductive aging (improving aged oocyte quality)
· Barth syndrome (FDA accelerated approval granted)
Data sheet
Manual confirmation- Material Type
- Single material
- Purity Identity
- ≥99% purity
- Molecular Weight
- 639.79 g/mol
- Pack Size
- 10mg
- Molecular Formula
- C32H49N9O5
- CAS Number
- 736992-21-5
- Amino Acid Sequence
- H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2
- PubChem CID
- 11764719
- Storage conditions overview
- Storage typeLong-termTemperature-80°CDuration2-3 yearsNotesSealed, dark, minimal openingStorage typeStandardTemperature-20°CDuration1-2 yearsNotesSealed, dark, moisture-proofStorage typeShort-termTemperature4°CDuration1-2 weeksNotesTemporary storage, use promptlyStorage typeWorking SolutionTemperature4°CDuration1-7 daysNotesReconstituted, short-term, avoid freeze-thaw
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